To clarify: do you want simulation of RF generation? if so, no.
If you want to simulate piezoelectric material in a waveguide, it might be doable: you can find the change of its refractive index by strain:
https://optics.ansys.com/hc/en-us/articles/360042762493-Spatially-varying-refractive-index-due-to-strain
With the material change, you can simulate the RF signal propagation in the waveguide (FDTD, varFDTD, DGTD or EME), or get the mode properties (FDE, FEEM).
FDTD, varFDTD, DGTD and EME simulate propagation whereas FDE and FEEM solve mode properties in waveguide. All solvers need correct material properties.
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