Atharv Joshi
Forum Moderator
Hi Naftali, 
 
You can create a defeature script, save a python file and we can run it from Command prompt.
Batch file can be also be created which launches SpaceClaim and runs the defeature script. 
 
I would recommend you reach out to Matlab support team and check possibility of launching SpaceClaim from Matlab or running the batch file. 
 
Thank 
Atharv