Best work around is to have the model you are continually modifying as one file, and then insert it into a new file as a component to create an assembly and do the drawings in there. If the drawing sheet qty is the issue, then only do a few drawing sheets in that file. Then repeat by creating a new file, and insert the model again as a component to do some more drawings. That way any changes made to the orginal componet will be reflected through all subsequent files used to hold the drawing information. It also means when you want to do mods on the gemometry, you don't load a single drawing into memory so your modelling will run smoother.
As far as memory leaks go though its not only drawings, see this post, Memory leakage, freezing slow performance (ansys.com), and this one Reply To: Space claim files grow in size… (ansys.com)
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