Reply To: Critical error while installing Ansys 2022 R2

[George Karnos]

 

Couple thoughts:
Make sure you extract to a temporary directory and then run setup.exe by right–clicking on it and choosing more-> “run as administrator”
Make sure Virus software is not blocking install.
Verify enough disk space.
Also, if you search this forum for :  manifest file  
There are other posts that may give ideas.