Ansys Assistant will be unavailable on the Learning Forum starting January 30. An upgraded version is coming soon. We apologize for any inconvenience and appreciate your patience. Stay tuned for updates.
George Karnos
Ansys Employee

I would first try the following:
Close all ANSYs Programs
Rename  the following directory:

%APPDATA%\Ansys\v242
to:
%APPDATA%\Ansys\v242.old

Note:   %APPDATA%\ usually translates to: C:\Users\\AppData\Roaming

Now try to run.

[bingo_chatbox]