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I would suggest to have a read through the following section of the help manual, which talks about modeling strategies:
25.8. Solution Strategies for Multiphase Modeling (ansys.com)
Generally its better to start with simpler models and numerics; obtain a reasonably converged solution and then build up the compexity of the multiphase simulations and restart the simulation. These types of simulations could necessitate long run times with timesteps being ramped from small values to larger values equivalent to the residence time in the domain so as to achieve mass, momentum & volume fraction balance.
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