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It depends on what you want to alter to see the result. Ie do you want to optimise something, if so what can you alter to acheive this. The tools will allow most settings to be changed, but you need to determine the limits: if I want to cool a room I could just spray a lot of cold water into it, it'll be cool but very wet..... Â
Have a look at the Design of Experiments functions in Workbench but also Adjoint in Fluent. There are also the new AI based tools,  https://www.ansys.com/technology-trends/artificial-intelligence to consider. Most of my work tends to be around making the base model do something complicated, and I leave optimsation etc to colleagues who specialise in that field.Â